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KMID : 0378119790060020429
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Chungnam Medical Journal
1979 Volume.6 No. 2 p.429 ~ p.438
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A Morphological Study on the Relationship between Stomach Cancer and Intestinal Metaplasia
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Abstract
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Study was made to investigate morphological relationships between gastric cancer and intestinal metaplasia developed in gastric mucosa.
Seventy-four cases of gastric cancer resected by gastrectomy were classified to Lauren´s method, i. e. the intestinal type carcinoma and diffuse carcincrra. Author observed the staining quality of mucin granules and the frequency and occurring of intestinal metapl￢asia histochemically, and ultrastructural variations between both types of gastric cancer and intestinal metaplasia.
The results obtained were as follows
1. Intestinal type carcinoma accounted for 58. 1% and diffuse carcinoma for 31. 1%.
2. The mean age of patients with intestinal type carcinoma was 54. 6 years and that diffuse carcinoma 46. 7 years.
3. The occurrence of intestinal metaplasia was noted 97. 7% in intestinal type carcin￢oma and 78.3;0 in diffuse carcinoma.
4. Regional distribution of intestinal metaplasia in gastric mucosa was not related to cancer types. The metaplasia most often involved pyloric region of lesser curvature and the region between pylorus and gastric body, and lowest in gastric body.
5. It seemed to be morphological resemblances between intestinal type carcinoma cells and intestinal metaplastic cells and between diffuse carcinoma cells and normal surface mucous cells on stainning quality of mucin granules and ultrastructually.
6. In regards to above results, intestinal type carcinoma may at least develop from intestinal metaplasia and it is likely that intestinal metaplasia is not precancerous lesion, but cancer-producible cell under carcinogenic influences.
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